Mahogany seed extract is a natural treatment for hypertension

Researchers from the Universiti Sains Malaysia in Malaysia have suggested using mahogany (Swietenia macrophylla) seed extract as a potential herbal medicine to treat hypertension. In their study, which was published in the Journal of Medicinal Food, they examined the antihypertensive and vasorelaxant effects of mahogany seed extract using both laboratory testing and clinical trials.

  • In Malaysia, mahogany seeds have been used as a folk medicine for the treatment of hypertension.
  • For the clinical trial, the researchers orally administered hypertensive mice with three different doses of mahogany seed extract: 250 milligrams per kilogram (mg/kg), 500 mg/kg, and 1,000 mg/kg each day for four weeks.
  • In addition, they measured the systolic blood pressure and diastolic blood pressure of mice every week.
  • For the laboratory testing, they used the Fourier Transform Infrared Spectroscopy (FITR) analysis.
  • The results of the FITR analysis revealed that the mahogany seed extract contains stachyose, flavonoids, limonoids, and ester, which may contribute to its vasorelaxant effect.
  • The antihypertensive and vasorelaxant effects of mahogany seed extract were mediated by voltage-operated calcium channels (VOCC), potassium channels, inositol triphosphate receptor (IP3R) inhibitor, G-protein-coupled ?2-adrenergic receptor, and the nitric oxide/soluble guanylyl cyclase/cyclic 3?,5?-guanosine monophosphate (NO/sGC/cGMP) signaling pathways.
  • The treatment of mahogany seed extract also reduced both systolic blood pressure and diastolic blood pressure in hypertensive mice.

In conclusion, the findings suggested that mahogany seed extract has the potential to be used as an herbal remedy for treating hypertension or high blood pressure.

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Journal Reference:

Ch’ng YS, Loh YC, Tan CS, Ahmad M, Asmawi MZ, Omar WMW, Yam MF. VASODILATION AND ANTIHYPERTENSIVE ACTIVITIES OF SWIETENIA MACROPHYLLA (MAHOGANY) SEED EXTRACT. Journal of Medicinal Food. 1 March 2018; 21(3). DOI: 10.1089/jmf.2017.4008

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